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Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms.

ABSTRACT: BACKGROUND:In 2013 German infection surveillance guidelines recommended weekly colonization screening for multidrug-resistant (MDRO) or highly epidemic organisms for neonatal intensive care units (NICUs) and extended hygiene measures based on screening results. It remains a matter of debate whether screening is worth the effort. We therefore aimed to evaluate sepsis related outcomes before and after the guideline update. METHODS:The German Neonatal Network (GNN) is a prospective cohort study including data from extremely preterm infants between 22?+?0 and 28?+?6 gestational weeks born in 62 German level III NICUs. RESULTS:Infants treated after guideline update (n?=?8.903) had a lower mortality (12.5% vs. 13.8%, p?=?0.036), reduced rates for clinical sepsis (31.4 vs. 42.8%, p?

SUBMITTER: Hartel C 

PROVIDER: S-EPMC7449086 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms.

Härtel Christoph C   Faust Kirstin K   Fortmann Ingmar I   Humberg Alexander A   Pagel Julia J   Haug Clara C   Kühl Reinhard R   Bohnhorst Bettina B   Pirr Sabine S   Viemann Dorothee D   Simon Arne A   Zemlin Michael M   Poralla Silvia S   Müller Andreas A   Köstlin-Gille Natascha N   Gille Christian C   Heckmann Matthias M   Rupp Jan J   Herting Egbert E   Göpel Wolfgang W  

Antimicrobial resistance and infection control 20200826 1

<h4>Background</h4>In 2013 German infection surveillance guidelines recommended weekly colonization screening for multidrug-resistant (MDRO) or highly epidemic organisms for neonatal intensive care units (NICUs) and extended hygiene measures based on screening results. It remains a matter of debate whether screening is worth the effort. We therefore aimed to evaluate sepsis related outcomes before and after the guideline update.<h4>Methods</h4>The German Neonatal Network (GNN) is a prospective c  ...[more]

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