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Genomic Analysis Reveals Antibiotic-Susceptible Clones and Emerging Resistance in Neisseria gonorrhoeae in Saskatchewan, Canada.

ABSTRACT: Whole-genome sequencing was used to identify mutations in antibiotic resistance-conferring genes to compare susceptibility predictions with MICs and to ascertain strain types in 99 isolates of Neisseria gonorrhoeae Genotypes associated with susceptibility, as well as MIC creep or emerging resistance, were noted. Phylogenomic analysis revealed three distinctive clades and putative gonococcal transmission linkages involving a tetracycline-resistant N. gonorrhoeae outbreak and the clonal spread of susceptible isolates in men.

SUBMITTER: Parmar NR 

PROVIDER: S-EPMC7449210 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Genomic Analysis Reveals Antibiotic-Susceptible Clones and Emerging Resistance in Neisseria gonorrhoeae in Saskatchewan, Canada.

Parmar Nidhi R NR   Singh Reema R   Martin Irene I   Perera Sumudu R SR   Demczuk Walter W   Kusalik Anthony A   Minion Jessica J   Dillon Jo-Anne R JR  

Antimicrobial agents and chemotherapy 20200820 9

Whole-genome sequencing was used to identify mutations in antibiotic resistance-conferring genes to compare susceptibility predictions with MICs and to ascertain strain types in 99 isolates of <i>Neisseria gonorrhoeae</i> Genotypes associated with susceptibility, as well as MIC creep or emerging resistance, were noted. Phylogenomic analysis revealed three distinctive clades and putative gonococcal transmission linkages involving a tetracycline-resistant <i>N. gonorrhoeae</i> outbreak and the clo  ...[more]

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