Ontology highlight
ABSTRACT:
SUBMITTER: Pais P
PROVIDER: S-EPMC7449212 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Pais Pedro P Califórnia Raquel R Galocha Mónica M Viana Romeu R Ola Mihaela M Cavalheiro Mafalda M Takahashi-Nakaguchi Azusa A Chibana Hiroji H Butler Geraldine G Teixeira Miguel C MC
Antimicrobial agents and chemotherapy 20200820 9
The ability to acquire azole resistance is an emblematic trait of the fungal pathogen <i>Candida glabrata</i> Understanding the molecular basis of azole resistance in this pathogen is crucial for designing more suitable therapeutic strategies. This study shows that the <i>C. glabrata</i> transcription factor (TF) CgRpn4 is a determinant of azole drug resistance. RNA sequencing during fluconazole exposure revealed that CgRpn4 regulates the expression of 212 genes, activating 80 genes and repressi ...[more]