Ontology highlight
ABSTRACT:
SUBMITTER: Stasiak JP
PROVIDER: S-EPMC7449261 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Tetrahedron letters 20190520 25
α-Hydroxytropolones (αHTs) have a wealth of biological activity owing to their ability to serve as metalbinding fragments for many therapeutically valuable dinuclear metalloenzymes. They also have the potential to exist in as many as 4 protonation states under aqueous acidic or basic conditions. The following details how UV absorption can be used to generate p<i>K</i> <sub>a</sub> values on a series of αHTs. The studies also provide some knowledge into how the acidity and basicity change with so ...[more]