Ontology highlight
ABSTRACT:
SUBMITTER: Pei J
PROVIDER: S-EPMC7449501 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Pei Jingwen J Zhang Yiming Y Nielsen Rasmus R Wu Yufeng Y
PLoS computational biology 20200814 8
Inference of admixture proportions is a classical statistical problem in population genetics. Standard methods implicitly assume that both parents of an individual have the same admixture fraction. However, this is rarely the case in real data. In this paper we show that the distribution of admixture tract lengths in a genome contains information about the admixture proportions of the ancestors of an individual. We develop a Hidden Markov Model (HMM) framework for estimating the admixture propor ...[more]