Ontology highlight
ABSTRACT:
SUBMITTER: Quick C
PROVIDER: S-EPMC7449570 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Quick Corbin C Anugu Pramod P Musani Solomon S Weiss Scott T ST Burchard Esteban G EG White Marquitta J MJ Keys Kevin L KL Cucca Francesco F Sidore Carlo C Boehnke Michael M Fuchsberger Christian C
Genetic epidemiology 20200609 6
A key aim for current genome-wide association studies (GWAS) is to interrogate the full spectrum of genetic variation underlying human traits, including rare variants, across populations. Deep whole-genome sequencing is the gold standard to fully capture genetic variation, but remains prohibitively expensive for large sample sizes. Array genotyping interrogates a sparser set of variants, which can be used as a scaffold for genotype imputation to capture a wider set of variants. However, imputati ...[more]