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ABSTRACT: Objective
To study two neutrophil activation markers, myeloid-related protein (MRP) 8/14 and neutrophil elastase (NE), for their ability to predict treatment response and flare in patients with JIA.Methods
Using samples from two cohorts (I and II), we determined MRP8/14 and NE levels of 32 (I) and 81 (II) patients with new-onset, DMARD-naïve arthritis and compared patients who responded to treatment (defined as fulfilling ≥ adjusted ACRpedi50 response and/or inactive disease) with non-responders (defined as fulfilling < adjusted ACRpedi50 response and/or active disease) at 6 and 12 months. Secondly, we compared biomarker levels of 54 (I) and 34 (II) patients with clinically inactive disease who did or did not suffer from a flare of arthritis after 6 or 12 months. Receiver operating characteristic analyses were carried out to study the predictive value of MRP8/14 and NE for treatment response and flare.Results
For both cohorts, baseline MRP8/14 and NE levels for patients who did or did not respond to treatment were not different. Also, MRP8/14 and NE levels were not different in patients who did or did not flare. Receiver operating characteristic analysis of MRP8/14 and NE demonstrated areas under the curve <0.7 in both cohorts.Conclusion
In our cohorts, MRP8/14 and NE could not predict treatment response. Also, when patients had inactive disease, neither marker could predict flares.
SUBMITTER: Barendregt AM
PROVIDER: S-EPMC7449815 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Barendregt Anouk M AM Veldkamp Saskia R SR Hissink Muller Petra C E PCE van de Geer Annemarie A Aarts Cathelijn C van Gulik E Charlotte EC Schilham Marco W MW Kessel Christoph C Keizer Mischa P MP Hemke Robert R Nassar-Sheikh Rashid Amara A Dolman Koert M KM Schonenberg-Meinema Dieneke D Ten Cate Rebecca R van den Berg J Merlijn JM Maas Mario M Kuijpers Taco W TW
Rheumatology (Oxford, England) 20200901 9
<h4>Objective</h4>To study two neutrophil activation markers, myeloid-related protein (MRP) 8/14 and neutrophil elastase (NE), for their ability to predict treatment response and flare in patients with JIA.<h4>Methods</h4>Using samples from two cohorts (I and II), we determined MRP8/14 and NE levels of 32 (I) and 81 (II) patients with new-onset, DMARD-naïve arthritis and compared patients who responded to treatment (defined as fulfilling ≥ adjusted ACRpedi50 response and/or inactive disease) wit ...[more]