Dataset Information

Functional neuroimaging in the acute phase of Takotsubo syndrome: volumetric and functional changes of the right insular cortex.

ABSTRACT: BACKGROUND:A brain-heart interaction has been proposed in Takotsubo syndrome (TTS). Structural changes in the limbic system and hypoconnectivity between certain brain areas in the chronic phase of the disease have been reported, but little is known concerning functional neuroimaging in the acute phase. We hypothesized anatomical and functional changes in the central nervous system and investigated whole-brain volumetric and functional connectivity alterations in the acute phase TTS patients compared to controls. METHODS:Anatomical and resting-state functional magnetic resonance imaging were performed in postmenopausal females: thirteen in the acute TTS phase and thirteen healthy controls without evidence of coronary artery disease. Voxel-based morphometry and graph theoretical analysis were applied to identify anatomical and functional differences between patients and controls. RESULTS:Significantly lower gray matter volumes were found in TTS patients in the right middle frontal gyrus (p?=?0.004) and right subcallosal cortex (p?=?0.009) compared to healthy controls. When lower threshold was applied, volumetric changes were noted in the right insular cortex (p?=?0.0113), the right paracingulate cortex (p?=?0.012), left amygdala (p?=?0.018), left central opercular cortex (p?=?0.017), right (p?=?0.013) and left thalamus (p?=?0.017), and left cerebral cortex (p?=?0.017). Graph analysis revealed significantly (p?

SUBMITTER: Dichtl W

PROVIDER: S-EPMC7449945 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Functional neuroimaging in the acute phase of Takotsubo syndrome: volumetric and functional changes of the right insular cortex.

Dichtl Wolfgang W Tuovinen Noora N Barbieri Fabian F Adukauskaite Agne A Senoner Thomas T Rubatscher Andrea A Hintringer Florian F Siedentopf Christian C Bauer Axel A Gizewski Elke R ER Steiger Ruth R

Clinical research in cardiology : official journal of the German Cardiac Society 20200130 9

<h4>Background</h4>A brain-heart interaction has been proposed in Takotsubo syndrome (TTS). Structural changes in the limbic system and hypoconnectivity between certain brain areas in the chronic phase of the disease have been reported, but little is known concerning functional neuroimaging in the acute phase. We hypothesized anatomical and functional changes in the central nervous system and investigated whole-brain volumetric and functional connectivity alterations in the acute phase TTS patie ...[more]

PMID: 32002630

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Project description:The functional organization of the primate insula has been studied using a variety of techniques focussing on regional differences in either architecture, connectivity, or function. These complementary methods offered insights into the complex organization of the insula and proposed distinct parcellation schemes at varying levels of detail and complexity. The advent of imaging techniques that allow non-invasive assessment of structural and functional connectivity, has popularized data-driven connectivity-based parcellation methods to investigate the organization of the human insula. Yet, it remains unclear if the subdivisions derived from these data-driven clustering methods reflect meaningful descriptions of the functional specialization of the insula. In this study, we employed hierarchical clustering to examine the cluster parcellations of the macaque insula. As our aim was exploratory, we examined parcellations consisting of two up to ten clusters. Three different cluster validation methods (fingerprinting, silhouette, elbow) converged on a four-cluster solution as the most optimal representation of our data. Examining functional response properties of these clusters, in addition to their brain-wide functional connectivity suggested a functional specialization related to processing gustatory, somato-motor, vestibular and social visual cues. However, a more detailed functional differentiation aligning with previous functional investigations of insula subfields became evident at higher cluster numbers beyond the proposed optimal four clusters. Overall, our findings demonstrate that resting-state-based hierarchical clustering can provide a meaningful description of the insula's functional organization at some level of detail. Nonetheless, cluster parcellations derived from this method are best combined with data obtained through other modalities, to provide a more comprehensive and detailed account of the insula's complex functional organization.

Dataset Information

Functional neuroimaging in the acute phase of Takotsubo syndrome: volumetric and functional changes of the right insular cortex.

Publications

Functional neuroimaging in the acute phase of Takotsubo syndrome: volumetric and functional changes of the right insular cortex.

Similar Datasets

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