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The association of body mass index with long-term clinical outcomes after ticagrelor monotherapy following abbreviated dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a prespecified sub-analysis of the GLOBAL LEADERS Trial.


ABSTRACT: BACKGROUND:The efficacy of antiplatelet therapies following percutaneous coronary intervention (PCI) may be affected by body mass index (BMI). METHODS AND RESULTS:This is a prespecified subgroup analysis of the GLOBAL LEADERS trial, a prospective, multicenter, open-label, randomized controlled trial in an all-comer population undergoing PCI, comparing the experimental strategy (23-month ticagrelor monotherapy following 1-month dual antiplatelet therapy [DAPT]) with a reference regimen (12-month aspirin monotherapy following 12-month DAPT). A total of 15,968 patients were stratified by baseline BMI with prespecified threshold of 27 kg/m2. Of those, 6973 (43.7%) patients with a BMI?

SUBMITTER: Ono M 

PROVIDER: S-EPMC7449952 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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The association of body mass index with long-term clinical outcomes after ticagrelor monotherapy following abbreviated dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a prespecified sub-analysis of the GLOBAL LEADERS Trial.

Ono Masafumi M   Chichareon Ply P   Tomaniak Mariusz M   Kawashima Hideyuki H   Takahashi Kuniaki K   Kogame Norihiro N   Modolo Rodrigo R   Hara Hironori H   Gao Chao C   Wang Rutao R   Walsh Simon S   Suryapranata Harry H   da Silva Pedro Canas PC   Cotton James J   Koning René R   Akin Ibrahim I   Rensing Benno J W M BJWM   Garg Scot S   Wykrzykowska Joanna J JJ   Piek Jan J JJ   Jüni Peter P   Hamm Christian C   Steg Philippe Gabriel PG   Valgimigli Marco M   Windecker Stephan S   Storey Robert F RF   Onuma Yoshinobu Y   Vranckx Pascal P   Serruys Patrick W PW  

Clinical research in cardiology : official journal of the German Cardiac Society 20200131 9


<h4>Background</h4>The efficacy of antiplatelet therapies following percutaneous coronary intervention (PCI) may be affected by body mass index (BMI).<h4>Methods and results</h4>This is a prespecified subgroup analysis of the GLOBAL LEADERS trial, a prospective, multicenter, open-label, randomized controlled trial in an all-comer population undergoing PCI, comparing the experimental strategy (23-month ticagrelor monotherapy following 1-month dual antiplatelet therapy [DAPT]) with a reference reg  ...[more]

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