Unknown

Dataset Information

0

The road ahead for health and lifespan interventions.


ABSTRACT: Aging is a modifiable risk factor for most chronic diseases and an inevitable process in humans. The development of pharmacological interventions aimed at delaying or preventing the onset of chronic conditions and other age-related diseases has been at the forefront of the aging field. Preclinical findings have demonstrated that species, sex and strain confer significant heterogeneity on reaching the desired health- and lifespan-promoting pharmacological responses in model organisms. Translating the safety and efficacy of these interventions to humans and the lack of reliable biomarkers that serve as predictors of health outcomes remain a challenge. Here, we will survey current pharmacological interventions that promote lifespan extension and/or increased healthspan in animals and humans, and review the various anti-aging interventions selected for inclusion in the NIA's Interventions Testing Program as well as the ClinicalTrials.gov database that target aging or age-related diseases in humans.

SUBMITTER: Gonzalez-Freire M 

PROVIDER: S-EPMC7450388 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

The road ahead for health and lifespan interventions.

Gonzalez-Freire Marta M   Diaz-Ruiz Alberto A   Hauser David D   Martinez-Romero Jorge J   Ferrucci Luigi L   Bernier Michel M   de Cabo Rafael R  

Ageing research reviews 20200225


Aging is a modifiable risk factor for most chronic diseases and an inevitable process in humans. The development of pharmacological interventions aimed at delaying or preventing the onset of chronic conditions and other age-related diseases has been at the forefront of the aging field. Preclinical findings have demonstrated that species, sex and strain confer significant heterogeneity on reaching the desired health- and lifespan-promoting pharmacological responses in model organisms. Translating  ...[more]

Similar Datasets

| S-EPMC5718207 | biostudies-literature
| S-EPMC10328293 | biostudies-literature
| S-EPMC9466315 | biostudies-literature
| S-EPMC3610617 | biostudies-other
| S-EPMC3510240 | biostudies-literature
| S-EPMC8033330 | biostudies-literature
| S-EPMC7770585 | biostudies-literature
| S-EPMC4907357 | biostudies-literature
| S-EPMC9684919 | biostudies-literature
| S-EPMC11347578 | biostudies-literature