Ontology highlight
ABSTRACT:
SUBMITTER: Chicote JU
PROVIDER: S-EPMC7450558 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chicote Javier U JU López-Sánchez Marcos M Marquès-Bonet Tomàs T Callizo José J Pérez-Jurado Luis A LA García-España Antonio A
BMC genomics 20200826 1
<h4>Background</h4>Duplications of large genomic segments provide genetic diversity in genome evolution. Despite their importance, how these duplications are generated remains uncertain, particularly for distant duplicated genomic segments.<h4>Results</h4>Here we provide evidence of the participation of circular DNA intermediates in the single generation of some large human segmental duplications. A specific reversion of sequence order from A-B/C-D to B-A/D-C between duplicated segments and the ...[more]