Real-time, high-resolution imaging of tumor cells in genetically engineered and orthotopic models of thyroid cancer.

ABSTRACT: Genetically engineered and orthotopic xenograft mouse models have been instrumental for increasing our understanding of thyroid cancer progression and for the development of novel therapeutic approaches in a setting that is more physiologically relevant than the classical subcutaneous flank implants. However, the anatomical location of the thyroid gland precludes a non-invasive analysis at the cellular level of the interactions between tumor cells and the surrounding microenvironment and does not allow a real-time evaluation of the response of tumor cells to drug treatments. As a consequence, such studies have generally only relied on endpoint approaches, limiting the amount and depth of the information that could be gathered. Here we describe the development of an innovative approach to i

SUBMITTER: Shanja-Grabarz X 

PROVIDER: S-EPMC7450603 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature