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Direct Amination of ?-Hydroxy Amides.

ABSTRACT: A TiCl4-mediated reaction for the direct amination of ?-hydroxy amides has been developed. This simple, general, additive/base/ligand-free reaction is mediated by economical TiCl4. The reaction runs under mild conditions. This highly efficient C-N bond formation protocol is valid for diverse amines, including primary, secondary and heterocyclic amines, and even a primary amide and indole.

SUBMITTER: Chandgude AL

PROVIDER: S-EPMC7451067 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Direct Amination of α-Hydroxy Amides.

Chandgude Ajay L AL Dömling Alexander A

Asian journal of organic chemistry 20170517 8

A TiCl<sub>4</sub>-mediated reaction for the direct amination of α-hydroxy amides has been developed. This simple, general, additive/base/ligand-free reaction is mediated by economical TiCl<sub>4</sub>. The reaction runs under mild conditions. This highly efficient C-N bond formation protocol is valid for diverse amines, including primary, secondary and heterocyclic amines, and even a primary amide and indole. ...[more]

PMID: 32864291

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