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Association of smoking with incident CKD risk in the general population: A community-based cohort study.


ABSTRACT: BACKGROUND:Chronic kidney disease (CKD) is a public health problem, and an unfavorable lifestyle has been suggested as a modifiable risk factor for CKD. Cigarette smoking is closely associated with cardiovascular disease and cancers; however, there is a lack of evidence to prove that smoking is harmful for kidney health. Therefore, we aimed to determine the relationship between cigarette smoking and CKD among healthy middle-aged adults. METHODS:Using the database from the Korean Genome and Epidemiology Study, we analyzed 8,661 participants after excluding those with baseline estimated glomerular filtration rate (eGFR)<60 ml/min/1.72 m2 or proteinuria. Exposure of interest was smoking status: never-, former-, and current-smokers. Primary outcome was incident CKD defined as eGFR <60 ml/min/1.73 m2 or newly developed proteinuria. RESULTS:The mean age of the subjects was 52 years, and 47.6% of them were males. There were 551 (6.4%) and 1,255 (14.5%) subjects with diabetes and hypertension, respectively. The mean eGFR was 93.0 ml/min/1.73 m2. Among the participants, 5,140 (59.3%), 1,336 (15.4%), and 2,185 (25.2%) were never-smokers, former-smokers, and current-smokers, respectively. During a median follow-up of 11.6 years, incident CKD developed in 1,941 (22.4%) subjects with a crude incidence rate of 25.1 (24.0-26.2) per 1,000 person-years. The multivariable Cox regression analysis after adjustment of confounding factors showed hazard ratios (95% confidence interval) of 1.13 (0.95-1.35) and 1.26 (1.07-1.48) for CKD development in the former- and current-smokers, compared with never-smokers. CONCLUSION:This study showed that smoking was associated with a higher risk of incident CKD among healthy middle-aged adults.

SUBMITTER: Jo W 

PROVIDER: S-EPMC7451569 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Association of smoking with incident CKD risk in the general population: A community-based cohort study.

Jo Wonji W   Lee Sangmi S   Joo Young Su YS   Nam Ki Heon KH   Yun Hae-Ryong HR   Chang Tae Ik TI   Kang Ea Wha EW   Yoo Tae-Hyun TH   Han Seung Hyeok SH   Kang Shin-Wook SW   Park Jung Tak JT   Park Jung Tak JT  

PloS one 20200827 8


<h4>Background</h4>Chronic kidney disease (CKD) is a public health problem, and an unfavorable lifestyle has been suggested as a modifiable risk factor for CKD. Cigarette smoking is closely associated with cardiovascular disease and cancers; however, there is a lack of evidence to prove that smoking is harmful for kidney health. Therefore, we aimed to determine the relationship between cigarette smoking and CKD among healthy middle-aged adults.<h4>Methods</h4>Using the database from the Korean G  ...[more]

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