Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC7452052 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Liu Chunyan C Zhang Ligang L Zhu Wenhui W Guo Raoqing R Sun Huamin H Chen Xi X Deng Ning N
Molecular therapy. Methods & clinical development 20200731
Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors for decades with the advantages of excellent biodegradability, biocompatibility, and high nucleic acid encapsulation efficiency. However, the clinical use of CLs in cancer gene therapy is limited because of many uncertain factors <i>in vivo</i>. Extracellular barriers such as opsonization, rapid clearance by the reticuloendothelial system and poor tumor penetration, and intracellular barriers, including endos ...[more]