Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC7452060 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Huang Yutang Y Dai Yi Y Wen Chunjie C He Shuai S Shi Jingjing J Zhao Dezhang D Wu Lanxiang L Zhou Honghao H
Molecular therapy. Nucleic acids 20200725
Gefitinib is a first-line treatment for patients with non-small-cell lung cancer (NSCLC), but acquired resistance is a major obstacle to its therapeutic efficacy, and the underlying mechanisms are not fully elucidated. Recent studies have indicated that circular RNAs play a crucial role in chemoresistance, but their expression and function in NSCLC cells with acquired resistance to gefitinib are largely unknown. In this study, we determined that circSETD3 was significantly upregulated in gefitin ...[more]