Ontology highlight
ABSTRACT:
SUBMITTER: Ge X
PROVIDER: S-EPMC7452114 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Molecular therapy. Nucleic acids 20200723
Increasing evidence indicates that lymphocyte cytosolic protein 1 (LCP1) overexpression contributes to tumor progression; however, its role in osteosarcoma (OS) remains unclear. We aimed to investigate the potential effect of LCP1 in OS and the underlying mechanisms. We first demonstrated that LCP1 is upregulated in OS cell lines and tissues. Then, we found that aberrant expression of LCP1 could induce the proliferation and metastasis of OS cells in vitro and in vivo by destabilizing neuregulin ...[more]