Ontology highlight
ABSTRACT:
SUBMITTER: Labibi B
PROVIDER: S-EPMC7452192 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Labibi Bita B Bashkurov Mikhail M Wrana Jeffrey L JL Attisano Liliana L
iScience 20200729 8
Integration of transforming growth factor β (TGF-β) signals with those of other pathways allows for precise temporal and spatial control of gene expression patterns that drive development and homeostasis. The Hippo pathway nuclear effectors, Taz/Yap, interact with the TGF-β transcriptional mediators, Smads, to control Smad activity. Key to TGF-β signaling is the nuclear localization of Smads. Thus, to investigate the role of Taz/Yap in Smad nuclear accumulation, we developed mathematical models ...[more]