Ontology highlight
ABSTRACT:
SUBMITTER: Hussain S
PROVIDER: S-EPMC7452741 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Hussain Sardar S Guruvayoorappan Chandrasekharan C Komal K P KP Ennaganti Sreenivasa S
Bioinformation 20200630 6
Cyclooxygenase-2 (COX-2) is linked to inflammation. Therefore, it is of interest to design and develop novel inhibitors for COX-2. Hence, we report the molecular docking based binding features of doronine derivatives (desacetyldoronine, floradnin, onetine, 22310115, 21159807) with the human Cyclooxygenase-2 as potential inhibitors. A pyrrolizidine alkaloid doronine a molecular constituents of Emilia sonchifolia is an herbal alternative to known drugs in the prophylaxis of inflammation. We report ...[more]