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Molecular docking analysis of Bcl-2 with phyto-compounds.

ABSTRACT: The Bcl-2 protein is liked in several cancers and drug resistance to therapy is also known in this context. There are many Bcl-2 inhibitors under clinical trials. It is of further interest to design new Bcl2 inhibitors from phyto compounds such as artesunate, bruceantin, maytansin, Salvicine, indicine N-oxide, kamebanin and oxyacanthine. We report the optimal binding features of these compounds with Bcl-2 for further consideration towards in vitro and in vivo validation.

SUBMITTER: Kirubhanand C

PROVIDER: S-EPMC7452744 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Molecular docking analysis of Bcl-2 with phyto-compounds.

Kirubhanand Chandrasekaran C Selvaraj Jayaraman J Rekha Umapathy Vidhya UV Vishnupriya Veeraraghavan V Sivabalan Venkatachalam V Manikannan Mathayan M Nalini Devarajan D Vijayalakshmi Periyasamy P Rajalakshmi Manikkam M Ponnulakshmi Rajagopal R

Bioinformation 20200630 6

The Bcl-2 protein is liked in several cancers and drug resistance to therapy is also known in this context. There are many Bcl-2 inhibitors under clinical trials. It is of further interest to design new Bcl2 inhibitors from phyto compounds such as artesunate, bruceantin, maytansin, Salvicine, indicine N-oxide, kamebanin and oxyacanthine. We report the optimal binding features of these compounds with Bcl-2 for further consideration towards in vitro and in vivo validation. ...[more]

PMID: 32884211

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