Ontology highlight
ABSTRACT:
SUBMITTER: Sun C
PROVIDER: S-EPMC7452928 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cellular and molecular life sciences : CMLS 20200305 18
The SF3b complex is an intrinsic component of the functional U2 small nuclear ribonucleoprotein (snRNP). As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. Since the discovery of SF3b, substantial progress has been made in elucidating its molecular mechanism during splicing. In addition, numerous recent studies indicate that SF3b and its components are engaged in various molecular ...[more]