Ontology highlight
ABSTRACT:
SUBMITTER: Petzer V
PROVIDER: S-EPMC7453149 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Petzer Verena V Tymoszuk Piotr P Asshoff Malte M Carvalho Joana J Papworth Jonathan J Deantonio Cecilia C Bayliss Luke L Wake Matthew Stephen MS Seifert Markus M Brigo Natascha N Valente de Souza Lara L Hilbe Richard R Grubwieser Philipp P Demetz Egon E Dichtl Stefanie S Volani Chiara C Berger Sylvia S Böhm Felix F Hoffmann Alexander A Pfeifhofer-Obermair Christa C von Raffay Laura L Sopper Sieghart S Arndt Stephanie S Bosserhoff Anja A Kautz Léon L Perrier Prunelle P Nairz Manfred M Wolf Dominik D Weiss Guenter G Germaschewski Volker V Theurl Igor I
Blood 20200801 9
Recombinant erythropoietin (EPO) and iron substitution are a standard of care for treatment of anemias associated with chronic inflammation, including anemia of chronic kidney disease. A black box warning for EPO therapy and concerns about negative side effects related to high-dose iron supplementation as well as the significant proportion of patients becoming EPO resistant over time explains the medical need to define novel strategies to ameliorate anemia of chronic disease (ACD). As hepcidin i ...[more]