Ontology highlight
ABSTRACT:
SUBMITTER: Milos G
PROVIDER: S-EPMC7453199 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Milos Gabriella G Antel Jochen J Kaufmann Lisa-Katrin LK Barth Nikolaus N Koller Antonia A Tan Susanne S Wiesing Urban U Hinney Anke A Libuda Lars L Wabitsch Martin M von Känel Roland R Hebebrand Johannes J
Translational psychiatry 20200827 1
To examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetitive thoughts of food, inner restlessness, and weight phobia decreased in two patients. Surprisingly, depression improved rapidly in all patients. No serious adverse events occurred. Due to obvious limi ...[more]