Ontology highlight
ABSTRACT:
SUBMITTER: Du Z
PROVIDER: S-EPMC7453385 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Du Zhen Z Chakrabarti Sampurna S Kulaberoglu Yavuz Y Smith Ewan St John ESJ Dobson Christopher M CM Itzhaki Laura S LS Kumita Janet R JR
Biochemical and biophysical research communications 20200803 4
The long-living naked mole-rat (NMR) shows negligible senescence and resistance to age-associated diseases. Recent evidence, based on protein-level assays, suggests that enhanced protein homeostasis machinery contributes to NMR stress-resistance and longevity. Here, we develop NMR-specific, transcriptional assays for measuring the unfolded protein response (UPR), a component of ER proteostasis. By varying doses and response times of pharmacological ER stressors applied to NMR kidney fibroblasts, ...[more]