Ontology highlight
ABSTRACT:
SUBMITTER: Guo X
PROVIDER: S-EPMC7453427 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Guo Xingyi X Long Jirong J Chen Zhishan Z Shu Xiao-Ou XO Xiang Yong-Bing YB Wen Wanqing W Zeng Chenjie C Gao Yu-Tang YT Cai Qiuyin Q Zheng Wei W
International journal of cancer 20191227 8
The missing heritability of breast cancer could be partially attributed to rare variants (MAF < 0.5%). To identify breast cancer-associated rare coding variants, we conducted whole-exome sequencing (~50×) in genomic DNA samples obtained from 831 breast cancer cases and 839 controls of Chinese females. Using burden tests for each gene that included rare missense or predicted deleterious variants, we identified 29 genes showing promising associations with breast cancer risk. We replicated the asso ...[more]