Ontology highlight
ABSTRACT:
SUBMITTER: Chuong C
PROVIDER: S-EPMC7453574 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chuong Christina C Bates Tyler A TA Akter Shamima S Werre Stephen R SR LeRoith Tanya T Weger-Lucarelli James J
BMC biology 20200827 1
<h4>Background</h4>Dengue virus (DENV) is estimated to infect 390 million people annually. However, few host factors that alter disease severity are known. Malnutrition, defined as both over- and undernutrition, is a growing problem worldwide and has long been linked to dengue disease severity by epidemiological and anecdotal observations. Accordingly, we sought to establish a mouse model to assess the impact of nutritional status on DENV disease severity.<h4>Results</h4>Using transiently immuno ...[more]