Poor survival after resection of early gastric cancer: extremes of survivorship analysis reveal distinct genomic profile.
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ABSTRACT:
SUBMITTER: Datta J
PROVIDER: S-EPMC7453628 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Poor survival after resection of early gastric cancer: extremes of survivorship analysis reveal distinct genomic profile.
Datta J J Da Silva E M EM Kandoth C C Song T T Russo A E AE Hernandez J M JM Taylor B S BS Janjigian Y Y YY Tang L H LH Solit D B DB Strong V E VE
The British journal of surgery 20191125 1
A subset of patients with early gastric cancer demonstrate early recurrence and poor survival despite margin-negative resection. This study used an extremes-of-survivorship approach to identify an association between TP53 hotspot mutations co-occurring with loss of heterozygosity and unexpectedly poor survival in early gastric cancer. This distinct genomic profile may be a novel biomarker of poor survival in patients with completely resected early gastric cancer, and warrants large-scale validat ...[more]
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