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Premigration social adversity and autism spectrum disorder.

ABSTRACT: BACKGROUND:Several studies suggest significant relationships between migration and autism spectrum disorder (ASD) but there are discrepant results. Given that no studies to date have included a pathological control group, the specificity of the results in ASD can be questioned. AIMS:To compare the migration experience (premigration, migratory trip, postmigration) in ASD and non-ASD pathological control groups, and study the relationships between migration and autism severity. METHOD:Parents' and grandparents' migrant status was compared in 30 prepubertal boys with ASD and 30 prepubertal boys without ASD but with language disorders, using a questionnaire including Human Development Index (HDI)/Inequality-adjusted Human Development Index (IHDI) of native countries. Autism severity was assessed using the Child Autism Rating Scale, Autism Diagnostic Observation Schedule and Autism Diagnostic Interview-Revised scales. RESULTS:The parents' and grandparents' migrant status frequency did not differ between ASD and control groups and was not associated with autism severity. The HDI/IHDI values of native countries were significantly lower for parents and grandparents of children with ASD compared with the controls, especially for paternal grandparents. Furthermore, HDI/IDHI levels from the paternal line (father and especially paternal grandparents) were significantly negatively correlated with autism severity, particularly for social interaction impairments. CONCLUSIONS:In this study, parents' and/or grandparents' migrant status did not discriminate ASD and pathological control groups and did not contribute either to autism severity. However, the HDI/IHDI results suggest that social adversity-related stress experienced in native countries, especially by paternal grandparents, is potentially a traumatic experience that may play a role in ASD development. A 'premigration theory of autism' is then proposed.

SUBMITTER: Augereau N

PROVIDER: S-EPMC7453802 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Premigration social adversity and autism spectrum disorder.

Augereau Natacha N Lagdas Ines I Kermarrec Solenn S Gicquel Ludovic L Martin Virginie V Xavier Jean J Cohen David D Bouvet Michel M Rolland Anne-Catherine AC Tordjman Sylvie S

BJPsych open 20200818 5

<h4>Background</h4>Several studies suggest significant relationships between migration and autism spectrum disorder (ASD) but there are discrepant results. Given that no studies to date have included a pathological control group, the specificity of the results in ASD can be questioned.<h4>Aims</h4>To compare the migration experience (premigration, migratory trip, postmigration) in ASD and non-ASD pathological control groups, and study the relationships between migration and autism severity.<h4>M ...[more]

PMID: 32807250

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Premigration social adversity and autism spectrum disorder.

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Premigration social adversity and autism spectrum disorder.

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