Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez AR
PROVIDER: S-EPMC7454203 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Rodriguez Ana R AR Spur Bernd W BW
Tetrahedron letters 20200319 20
The first total synthesis of the pro-resolving lipid mediator 7(<i>S</i>),12(<i>R</i>),13(<i>S</i>)-Resolvin T2 [7(<i>S</i>), 12(<i>R</i>), 13(<i>S</i>)-RvT2] and its 13(<i>R</i>)-epimer, derived from n-3 docosapentaenoic acid (n-3 DPA), are described. 7(<i>S</i>), 12(<i>R</i>), 13(<i>S</i>)-RvT2 and its 13(<i>R</i>)-epimer were obtained by total synthesis using a chiral pool strategy to introduce the chiral centers. C7 was generated from <i>S</i>-(-)-1,2,4-butanetriol in both molecules and the ...[more]