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Factors associated with viral load kinetics of Middle East respiratory syndrome coronavirus during the 2015 outbreak in South Korea.


ABSTRACT: We conducted a retrospective study of Middle East respiratory syndrome coronavirus (MERS-CoV) viral load kinetics using data from patients hospitalised with MERS-CoV infection between 19 May and 20 August, 2015. Viral load trajectories were considered over the hospitalisation period using 1,714 viral load results measured in serial respiratory specimens of 185 patients. The viral load levels were significantly higher among non-survivors than among survivors (p=0.003). Healthcare workers (p = 0.001) and non-spreaders (p <0.001) had significantly lower viral loads. Viral RNA was present on the day of symptom onset and peaked 4-10 days after symptom onset.

SUBMITTER: Yang JS 

PROVIDER: S-EPMC7454697 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Factors Associated With Viral Load Kinetics of Middle East Respiratory Syndrome Coronavirus During the 2015 Outbreak in South Korea.

Yang Jeong-Sun JS   Yoo Min-Gyu MG   Lee Hye-Ja HJ   Jang Han Byul HB   Jung Hee-Dong HD   Nam Jeong-Gu JG   Lee Joo-Yeon JY   Jee Youngmee Y   Kim Sung Soon SS  

The Journal of infectious diseases 20210301 6


We conducted a retrospective study of Middle East respiratory syndrome coronavirus (MERS-CoV) viral load kinetics using data from patients hospitalized with MERS-CoV infection between 19 May and 20 August 2015. Viral load trajectories were considered over the hospitalization period using 1714 viral load results measured in serial respiratory specimens of 185 patients. The viral load levels were significantly higher among nonsurvivors than among survivors (P = .003). Healthcare workers (P = .001)  ...[more]

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