Ontology highlight
ABSTRACT:
SUBMITTER: Duan H
PROVIDER: S-EPMC7455064 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Duan Hao H He Zhenqiang Z Lin Maohuan M Wang Yanling Y Yang Fan F Mitteer R Alan RA Kim Hyun-Jun HJ Yeo Eujing E Han Hongyu H Qin Ling L Fan Yi Y Gong Yanqing Y
JCI insight 20200806 15
Stem cell transplantation has emerged as a promising strategy in regenerative medicine. However, the poor survival and persistence of the transplanted cells, including mesenchymal stem cells (MSCs), in the hostile ischemic microenvironments represents a major therapeutic barrier. Here we report that plasminogen (Plg) stimulated MSC functions and promoted MSC survival during tissue repair after ischemia. Genetic Plg ablation abolished MSC survival, migration, and proliferation in mouse ischemic l ...[more]