Ontology highlight
ABSTRACT:
SUBMITTER: Shui Y
PROVIDER: S-EPMC7455501 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Shui Yuan Y Liu Ping P Zhan Haiying H Chen Bojun B Wang Zhao-Wen ZW
Science advances 20200703 27
Rectifying electrical synapses (RESs) exist across animal species, but their rectification mechanism is largely unknown. We investigated why RESs between AVA premotor interneurons and A-type cholinergic motoneurons (A-MNs) in <i>Caenorhabditis elegans</i> escape circuit conduct junctional currents (<i>I</i> <sub>j</sub>) only in the antidromic direction. These RESs consist of UNC-7 innexin in AVA and UNC-9 innexin in A-MNs. UNC-7 has multiple isoforms differing in the length and sequence of the ...[more]