Syntaxin 3 is essential for photoreceptor outer segment protein trafficking and survival.
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ABSTRACT:
SUBMITTER: Kakakhel M
PROVIDER: S-EPMC7456102 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Syntaxin 3 is essential for photoreceptor outer segment protein trafficking and survival.
Kakakhel Mashal M Tebbe Lars L Makia Mustafa S MS Conley Shannon M SM Sherry David M DM Al-Ubaidi Muayyad R MR Naash Muna I MI
Proceedings of the National Academy of Sciences of the United States of America 20200810 34
Trafficking of photoreceptor membrane proteins from their site of synthesis in the inner segment (IS) to the outer segment (OS) is critical for photoreceptor function and vision. Here we evaluate the role of syntaxin 3 (STX3), in trafficking of OS membrane proteins such as peripherin 2 (PRPH2) and rhodopsin. Photoreceptor-specific <i>Stx3</i> knockouts [<i>Stx3</i><sup><i>f/f(iCre75)</i></sup> and <i>Stx3</i><sup><i>f/f(CRX-Cre)</i></sup> ] exhibited rapid, early-onset photoreceptor degeneration ...[more]
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