Ontology highlight
ABSTRACT:
SUBMITTER: Huang KM
PROVIDER: S-EPMC7456253 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20200901 9
Peripheral neurotoxicity is a debilitating condition that afflicts up to 90% of patients with colorectal cancer receiving oxaliplatin-containing therapy. Although emerging evidence has highlighted the importance of various solute carriers to the toxicity of anticancer drugs, the contribution of these proteins to oxaliplatin-induced peripheral neurotoxicity remains controversial. Among candidate transporters investigated in genetically engineered mouse models, we provide evidence for a critical r ...[more]