Gene Delivery to the Skin - How Far Have We Come?
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ABSTRACT:
SUBMITTER: Ain QU
PROVIDER: S-EPMC7456264 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Gene Delivery to the Skin - How Far Have We Come?
Ain Qurrat Ul QU Campos Estefania V R EVR Huynh Ariel A Witzigmann Dominik D Hedtrich Sarah S
Trends in biotechnology 20200829 5
Gene therapies are powerful tools to prevent, treat, and cure human diseases. The application of gene therapies for skin diseases received little attention so far, despite the easy accessibility of skin and the urgent medical need. A major obstacle is the unique barrier properties of human skin, which significantly limits the absorption of biomacromolecules, and thus hampers the efficient delivery of nucleic acid payloads. In this review, we discuss current approaches, successes, and failures of ...[more]
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