Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder.

ABSTRACT:

Objective

Studies on alterations in the regional neural activity in the brain of patients with bipolar disorder (BD) have provided conflicting results because of different medications used and study designs. A low bone mineral density (BMD) is also observed in patients with BD. This study aimed to further explore regional neural activities in unmedicated patients with BD and their association with BMD.

Methods

In this study, 40 patients with BD and 42 healthy controls were scanned through resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo) and pattern classification. Pearson's correlation analyses were performed to explore the correlations between abnormal ReHo and BMD.

Results

A significant increase

SUBMITTER: Shan X 

PROVIDER: S-EPMC7456987 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature