Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC7457018 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wang Qimin Q Zhang Yuling Y Zou Peng P Wang Meixiang M Fu Weihui W She Jialei J Song Zhigang Z Xu Jianqing J Huang Jinghe J Wu Fan F
Frontiers in microbiology 20200814
The extracellular domain of influenza M2 protein (M2e) is highly conserved and is a promising target for development of universal influenza vaccines. Here, we synthesized a peptide vaccine consisting of M2e epitope linked to a fibrillizing peptide, which could self-assemble into nanoparticle in physiological salt solutions. When administrated into mice without additional adjuvant, the influenza A M2e epitope-bearing nanoparticles induced antibodies against M2e of different influenza subtypes. Co ...[more]