Ontology highlight
ABSTRACT:
SUBMITTER: Dilworth D
PROVIDER: S-EPMC7457334 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Dilworth David D Gong Fade F Miller Kyle K Nelson Christopher J CJ
Biochemistry and cell biology = Biochimie et biologie cellulaire 20190108 1
FK506-binding proteins (FKBPs) alter the conformation of proteins via <i>cis-trans</i> isomerization of prolyl-peptide bonds. While this activity can be demonstrated in vitro, the intractability of detecting prolyl isomerization events in cells has limited our understanding of the biological processes regulated by FKBPs. Here we report that FKBP25 is an active participant in the repair of DNA double-strand breaks (DSBs). FKBP25 influences DSB repair pathway choice by promoting homologous recombi ...[more]