Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.
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ABSTRACT:
SUBMITTER: Aguirre S
PROVIDER: S-EPMC7457382 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.
Aguirre Sebastian S Luthra Priya P Sanchez-Aparicio Maria T MT Maestre Ana M AM Patel Jenish J Lamothe Francise F Fredericks Anthony C AC Tripathi Shashank S Zhu Tongtong T Pintado-Silva Jessica J Webb Laurence G LG Bernal-Rubio Dabeiba D Solovyov Alexander A Greenbaum Benjamin B Simon Viviana V Basler Christopher F CF Mulder Lubbertus C F LC García-Sastre Adolfo A Fernandez-Sesma Ana A
Nature microbiology 20170327
During the last few decades, the global incidence of dengue virus (DENV) has increased dramatically, and it is now endemic in more than 100 countries. To establish a productive infection in humans, DENV uses different strategies to inhibit or avoid the host innate immune system. Several DENV proteins have been shown to strategically target crucial components of the type I interferon system. Here, we report that the DENV NS2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase (cGAS) ...[more]
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