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Characteristics of cognitive impairment in adult asymptomatic moyamoya disease.


ABSTRACT: BACKGROUND:Cognitive impairment in adult moyamoya disease (MMD) is thought to be the result of ischemic stroke; however, the presence and extent of cognitive decline in asymptomatic patients is unclear. METHODS:After classification using T2-weighted fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), a total of 19 MMD patients with a history of cerebral infarction, 21 asymptomatic MMD patients, and 20 healthy controls matched for age, sex, and years of education were prospectively included in this study. A detailed neuropsychological evaluation of two moyamoya subgroups and normal controls was conducted. RESULTS:Asymptomatic patients showed varying degrees of decline in intelligence (Raven's Standard Progressive Matrices, P?=?0.001), spatial imagination (mental rotation, P?=?0.014), working memory (verbal working memory-backward digit span, P?=?0.011), and computational ability (simple subtraction, P?=?0.014; complex subtraction, P?

SUBMITTER: He S 

PROVIDER: S-EPMC7457758 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Characteristics of cognitive impairment in adult asymptomatic moyamoya disease.

He Shihao S   Duan Ran R   Liu Ziqi Z   Ye Xun X   Yuan Li L   Li Tian T   Tan Cunxin C   Shao Junshi J   Qin Shusen S   Wang Rong R  

BMC neurology 20200831 1


<h4>Background</h4>Cognitive impairment in adult moyamoya disease (MMD) is thought to be the result of ischemic stroke; however, the presence and extent of cognitive decline in asymptomatic patients is unclear.<h4>Methods</h4>After classification using T2-weighted fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), a total of 19 MMD patients with a history of cerebral infarction, 21 asymptomatic MMD patients, and 20 healthy controls matched for age, sex, and years of ed  ...[more]

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