Improved Parkinsons disease motor score in a single-arm open-label trial of febuxostat and inosine.
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ABSTRACT:
SUBMITTER: Watanabe H
PROVIDER: S-EPMC7458241 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Improved Parkinsons disease motor score in a single-arm open-label trial of febuxostat and inosine.
Watanabe Hirohisa H Hattori Tatsuya T Kume Akito A Misu Kenichiro K Ito Takashi T Koike Yu Y Johnson Todd A TA Kamitsuji Shigeo S Kamatani Naoyuki N Sobue Gen G
Medicine 20200801 35
<h4>Background</h4>Cellular energetics play an important role in Parkinsons disease etiology, but no treatments directly address this deficiency. Our past research showed that treatment with febuxostat and inosine increased blood hypoxanthine and ATP in healthy adults, and a preliminary trial in 3 Parkinson's disease patients suggested some symptomatic improvements with no adverse effects.<h4>Methods</h4>To examine the efficacy on symptoms and safety in a larger group of Parkinsons disease patie ...[more]
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