Ontology highlight
ABSTRACT:
SUBMITTER: Daly CA
PROVIDER: S-EPMC7458396 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Daly Carole A CA Smit Martine J MJ Plouffe Bianca B
Biochemical Society transactions 20200801 4
US28 is a viral G protein-coupled receptor (GPCR) encoded by the human cytomegalovirus (HCMV). This receptor, expressed both during lytic replication and viral latency, is required for latency. US28 is binding to a wide variety of chemokines but also exhibits a particularly high constitutive activity robustly modulating a wide network of cellular pathways altering the host cell environment to benefit HCMV infection. Several studies suggest that US28-mediated signalling may contribute to cancer p ...[more]