Lurbinectedin: an FDA-approved inducer of immunogenic cell death for the treatment of small-cell lung cancer.
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ABSTRACT:
SUBMITTER: Kepp O
PROVIDER: S-EPMC7458590 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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Lurbinectedin: an FDA-approved inducer of immunogenic cell death for the treatment of small-cell lung cancer.
Kepp Oliver O Zitvogel Laurence L Kroemer Guido G
Oncoimmunology 20200721 1
Lurbinectedin is a DNA-binding inhibitor of transcription that potently induces immunogenic cell death (ICD). In June 2020, the Federal Drug Administration (FDA) approved lurbinectedin for the salvage treatment of small-cell lung cancer that has relapsed from platinum compound-based first-line chemotherapy. Thus, the clinical activity of lurbinectedin may originate, at least in part, from the induction of ICD. ...[more]
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