Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad TR
PROVIDER: S-EPMC7458818 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ahmad Tiara R TR Higuchi Sei S Bertaggia Enrico E Hung Allison A Shanmugarajah Niroshan N Guilz Nicole C NC Gamarra Jennifer R JR Haeusler Rebecca A RA
The Journal of biological chemistry 20200720 35
Bile acids (BAs) comprise heterogenous amphipathic cholesterol-derived molecules that carry out physicochemical and signaling functions. A major site of BA action is the terminal ileum, where enterocytes actively reuptake BAs and express high levels of BA-sensitive nuclear receptors. BA pool size and composition are affected by changes in metabolic health, and vice versa. One of several factors that differentiate BAs is the presence of a hydroxyl group on C12 of the steroid ring. 12α-Hydroxylate ...[more]