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IDOL gene variant is associated with hyperlipidemia in Han population in Xinjiang, China.

ABSTRACT: Hyperlipidemia is one of the main risk factors that contributed to atherosclerosis and coronary artery disease (CAD). In the present study, our objective was to explore whether some genetic variants of human IDOL gene were associated with hyperlipidemia among Han population in Xinjiang, China. We designed a case-control study. A total of 1,172 subjects (588 diagnosed hyperlipidemia cases and 584 healthy controls) of Chinese Han were recruited. We genotyped three SNPs (rs9370867, rs909562, and rs2072783) of IDOL gene in all subjects by using the improved multiplex ligation detection reaction (iMLDR) method. Our study demonstrated that the distribution of the genotypes, the dominant model (AA vs GG?+?GA), and the overdominant model (AA?+?GG vs GA) of the rs9370867 SNP had significant differences between the case group and controls (all P?

SUBMITTER: Adi D

PROVIDER: S-EPMC7459279 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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IDOL gene variant is associated with hyperlipidemia in Han population in Xinjiang, China.

Adi Dilare D Abuzhalihan Jialin J Wang Ying-Hong YH Baituola Gulinaer G Wu Yun Y Xie Xiang X Fu Zhen-Yan ZY Yang Yi-Ning YN Ma Xiang X Li Xiao-Mei XM Chen Bang-Dang BD Liu Fen F Ma Yi-Tong YT

Scientific reports 20200831 1

Hyperlipidemia is one of the main risk factors that contributed to atherosclerosis and coronary artery disease (CAD). In the present study, our objective was to explore whether some genetic variants of human IDOL gene were associated with hyperlipidemia among Han population in Xinjiang, China. We designed a case-control study. A total of 1,172 subjects (588 diagnosed hyperlipidemia cases and 584 healthy controls) of Chinese Han were recruited. We genotyped three SNPs (rs9370867, rs909562, and rs ...[more]

PMID: 32868861

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Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China.

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| S-EPMC8042894 | biostudies-literature

Diplotypes of CYP2C9 gene is associated with coronary artery disease in the Xinjiang Han population for women in China.

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Project description:Hyperlipidemia is one of the main risk factors for coronary artery disease (CAD). In the present study, we aimed to explore whether the single-nucleotide polymorphisms (SNPs) in amyloid precursor-like protein (APLP) 2 (APLP2) gene were associated with high lipid levels in Chinese population in Xinjiang, China. We recruited 1738 subjects (1187 men, 551 women) from the First Affiliated Hospital of Xinjiang Medical University, and genotyped three SNPs (rs2054247, rs3740881 and rs747180) of APLP2 gene in all subjects by using the improved multiplex ligation detection reaction (iMLDR) method. Our study revealed that the rs2054247 SNP was associated with serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) levels, and high-density lipoprotein cholesterol (HDL-C) in additive model (all P<0.05). The rs747180 SNP was associated with serum TC and LDL-C levels in additive model (all P<0.05). Our study revealed that both rs2054247 and rs747180 SNPs of the APLP2 gene were associated with high TC and LDL-C levels in Chinese subjects in Xinjiang.

| S-EPMC7403944 | biostudies-literature

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