Unknown

Dataset Information

0

Mirtazapine Reduces Adipocyte Hypertrophy and Increases Glucose Transporter Expression in Obese Mice.


ABSTRACT: Metabolic syndrome is known to engender type 2 diabetes as well as some cardiac, cerebrovascular, and kidney diseases. Mirtazapine-an atypical second-generation antipsychotic drug with less severe side effects than atypical first-generation antipsychotics-may have positive effects on blood glucose levels and obesity. In our executed study, we treated male high-fat diet (HFD)-fed C57BL/6J mice with mirtazapine (10 mg/kg/day mirtazapine) for 4 weeks to understand its antiobesity effects. We noted these mice to exhibit lower insulin levels, daily food efficiency, body weight, serum triglyceride levels, aspartate aminotransferase levels, liver and epididymal fat pad weight, and fatty acid regulation marker expression when compared with their counterparts (i.e., HFD-fed control mice). Furthermore, we determined a considerable drop in fatty liver scores and mean fat cell size in the epididymal white adipose tissue in the treated mice, corresponding to AMP-activated protein kinase expression activation. Notably, the treated mice showed lower glucose tolerance and blood glucose levels, but higher glucose transporter 4 expression. Overall, the aforementioned findings signify that mirtazapine could reduce lipid accumulation and thus prevent HFD-induced increase in body weight. In conclusion, mirtazapine may be useful in body weight control and antihyperglycemia therapy.

SUBMITTER: Wu CF 

PROVIDER: S-EPMC7459487 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Mirtazapine Reduces Adipocyte Hypertrophy and Increases Glucose Transporter Expression in Obese Mice.

Wu Ching-Feng CF   Hou Po-Hsun PH   Mao Frank Chiahung FC   Su Yao-Chi YC   Wu Ching-Yang CY   Yang Wei-Cheng WC   Lin Chen-Si CS   Tsai Hsiao-Pei HP   Liao Huei-Jyuan HJ   Chang Geng-Ruei GR  

Animals : an open access journal from MDPI 20200814 8


Metabolic syndrome is known to engender type 2 diabetes as well as some cardiac, cerebrovascular, and kidney diseases. Mirtazapine-an atypical second-generation antipsychotic drug with less severe side effects than atypical first-generation antipsychotics-may have positive effects on blood glucose levels and obesity. In our executed study, we treated male high-fat diet (HFD)-fed C57BL/6J mice with mirtazapine (10 mg/kg/day mirtazapine) for 4 weeks to understand its antiobesity effects. We noted  ...[more]

Similar Datasets

| S-EPMC5550562 | biostudies-other
| S-EPMC4190113 | biostudies-literature
| S-EPMC8612524 | biostudies-literature
| S-EPMC6727421 | biostudies-literature
| S-EPMC2842463 | biostudies-literature
| S-EPMC2480596 | biostudies-other
| S-EPMC5931531 | biostudies-literature
| S-EPMC2705860 | biostudies-other
| S-EPMC1602287 | biostudies-literature
| S-EPMC3962614 | biostudies-literature