Ontology highlight
ABSTRACT:
SUBMITTER: Kalfert D
PROVIDER: S-EPMC7459507 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Diagnostics (Basel, Switzerland) 20200805 8
MiR-34a belongs to the class of small non-coding regulatory RNAs and functions as a tumor suppressor. Under physiological conditions, miR-34a has an inhibitory effect on all processes related to cell proliferation by targeting many proto-oncogenes and silencing them on the post-transcriptional level. However, deregulation of miR-34a was shown to play important roles in tumorigenesis and processes associated with cancer progression, such as tumor-associated epithelial-mesenchymal transition, inva ...[more]