Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki S
PROVIDER: S-EPMC7460424 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Suzuki Shuhei S Yamamoto Masahiro M Sanomachi Tomomi T Togashi Keita K Sugai Asuka A Seino Shizuka S Okada Masashi M Yoshioka Takashi T Kitanaka Chifumi C
Biomedicines 20200805 8
Osimertinib, which is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is an important anticancer drug because of its high efficacy and excellent safety profile. However, resistance against osimertinib is inevitable; therefore, therapeutic strategies to overcome the resistance are needed. Doxazosin, a classic quinazoline-based alpha 1-adrenoceptor antagonist is used to treat hypertension and benign prostatic hyperplasia with a known safety profile. The anticancer ef ...[more]