Ontology highlight
ABSTRACT:
SUBMITTER: Andres M
PROVIDER: S-EPMC7460583 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Andrés Marta M García-Gomis Daniel D Ponte Inma I Suau Pedro P Roque Alicia A
International journal of molecular sciences 20200818 16
Histone H1 is the most variable histone and its role at the epigenetic level is less characterized than that of core histones. In vertebrates, H1 is a multigene family, which can encode up to 11 subtypes. The H1 subtype composition is different among cell types during the cell cycle and differentiation. Mass spectrometry-based proteomics has added a new layer of complexity with the identification of a large number of post-translational modifications (PTMs) in H1. In this review, we summarize his ...[more]