Ontology highlight
ABSTRACT:
SUBMITTER: Bocanegra A
PROVIDER: S-EPMC7460585 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Bocanegra Ana A Blanco Ester E Fernandez-Hinojal Gonzalo G Arasanz Hugo H Chocarro Luisa L Zuazo Miren M Morente Pilar P Vera Ruth R Escors David D Kochan Grazyna G
International journal of molecular sciences 20200818 16
The use of monoclonal antibodies targeting PD-1/PD-L1 axis completely changed anticancer treatment strategies. However, despite the significant improvement in overall survival and progression-free survival of patients undergoing these immunotherapy treatments, the only clinically accepted biomarker with some prediction capabilities for the outcome of the treatment is PD-L1 expression in tumor biopsies. Nevertheless, even when having PD-L1-positive tumors, numerous patients do not respond to thes ...[more]